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BCS written syllabus
General and technical cadres · 235 pages
Compulsory subjects and post-related subjects for professional and technical cadres. Confirm the applicable subject code in the recruitment notice.
Published by BPSC. Collected 2026-11-14. Confirm the edition and subject against your recruitment notice before studying.
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SYLLABUS FOR BCS (WRITTEN) EXAMINATION
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BIOCHEMISTRY
Part-II
Marks-100
A. Intermediary Metabolism:
(i) Enzymes, characteristics, classification, active sites, enzyme activity units, factors affection
enzyme activit, Michaelis -Menten equation, significances of Km and Vmax, Inhibition of
enzymes, Allosteric enzymes.
(ii) Carbohydrate Metabolism: Glycolysis, TCA cycles, Pentose phosphate pathway -their
regulation and energetics. Gluconeogenesis.
(iii) Lipid metabolism: Detradation of triglycerides and phospholipids, oxidation of fatty acids,
ketone bodies, production of energy by complete oxidation of palmatic acid, fatty acic
biosynthesis and its regulation, biosynthesis of cholesterol.
(iv) Protein Metabolism: Outline of metabolism of amino acids by transamination, deamination
and decarboxylation, glucogenic and ketogenic amino acids, urea cycles.
B. Physiology:
(i) Blood: composition, function, blood cells, blood grouping, Heart structure and coronary heart
diseases.
(ii) Digestion: Dtructure of the gastrointestinal tract, composition of digestive juices, Digestion
and absorption of carbohydrates, proteins and fat.
(iii) Structure and functions of liver, lung and kidney.
C. Endocrinology:
Classification of hormones, mechanism of hormone actions, synthesis, physiological
functions and biochemical functions of Pituitary, thyroid, parathyroid, pancreatic and gonad
hormones.
D. Clinical Biochemistry:
1) Diagnostic importance of ALT, AST, CK, LDH, acid phosphotase, alkaline phosphotas, urea,
uric acid, billirubin, glucose, cholesterol, calcium ion, iron ion, phosphate and bicarbonate
ion. Genetic basis of some Biochemical disorders-phenylketonuria, alkaptouria, sickle cell
anemia, thalsamia, gout.
2) Biochemistry of some diseases: Diabetes, Jaundice, Cholera, Diarrhoea.
E. Molecular Biology:
(i) DNA replication, Structure of m-RNA. Transcription, structures of t-RNA and ribosomes,
Translation, Genetic code, Mutation, DNA sequencing, Northern blotting, Southern blotting
and Western blotting.
(ii) Restriction enzymes, Vectors, DNA ligase, Cutting and joining of DNA, cDNA, reverse
transcriptase, transformation. Host control restriction and modification, cloning of particular
gene in different vectors, Polymerase chain reaction (PCR), Human Genome Project.
(iii) Regulation of Gene expression, Lac operon and arabinose operon, catabolic repression.